索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]谢怡,张敏,蒋利.线粒体源性肽Humanin 对心血管疾病的保护作用[J].国际心血管病杂志,2022,06:330-332.
点击复制

线粒体源性肽Humanin 对心血管疾病的保护作用(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2022年06期
页码:
330-332
栏目:
综述
出版日期:
2022-12-20

文章信息/Info

Title:
-
作者:
谢怡; 张敏; 蒋利
200336 上海交通大学医学院附属同仁医院心内科
Author(s):
-
关键词:
Humanin; 心血管疾病; 氧化应激; 细胞凋亡; 炎性反应
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2022.06.003
文献标识码:
-
摘要:
线粒体源性肽（MDP）是由线粒体DNA 编码的一系列内源性分泌性多肽，其 中Humanin 是最早发现的MDP。Humanin 广泛分布于心脏、血管壁、肾脏、骨骼肌和结肠 等组织中，在体内和体外均表现出抗氧化应激、抗凋亡、抗炎性反应的作用。Humanin 在心 血管疾病的发生发展中具有重要作用，该文介绍Humanin 及其修饰物在动脉粥样硬化、心肌 缺血再灌注损伤、心肌纤维化、冠脉微循环障碍中的保护作用及可能机制。
Abstract:
-

参考文献/References

[1] Nashine S, Kenney MC. Effects of mitochondrial-derived peptides (MDPs) on mitochondrial and cellular health in AMD[J]. Cells, 2020, 9(5):1102.
[2] Hashimoto Y, Niikura T, Tajima H, et al. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta[J]. Proc Natl Acad Sci U S A, 2001, 98(11):6336-6341.
[3] Yen K, Lee CH, Mehta H, et al. The emerging role of the mitochondrial-derived peptide humanin in stress resistance[J]. J Mol Endocrinol, 2013, 50(1):R11-R19.
[4] Yen K, Mehta HH, Kim SJ, et al. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan[J]. Aging (Albany NY), 2020, 12(12):11185-11199.
[5] Hazafa A, Batool A, Ahmad S, et al. Humanin: a mitochondrial-derived peptide in the treatment of apoptosisrelated diseases[J]. Life Sci, 2021, 264:118679.
[6] Cai H, Cao PY, Sun WQ, et al. Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans[J]. Biochim Biophys Acta Gen Subj, 2022, 1866(1):130010.
[7] El Kattawy HA, Abozaid ER, Abdullah DM. Humanin ameliorates late-onset hypogonadism in aged male rats[J]. Curr Mol Pharmacol, 2022, 15(7):996-1008.
[8] Zhang JH, Lei HW, Li X. The protective effects of S14Ghumanin (HNG) against mono-sodium urate (MSU) crystalsinduced gouty arthritis[J]. Bioengineered, 2022, 13(1):345- 356.
[9] Bachar AR, Scheffer L, Schroeder AS, et al. Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress[J]. Cardiovasc Res, 2010, 88(2):360-366.
[10] Oh YK, Bachar AR, Zacharias DG, et al. Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice[J]. Atherosclerosis, 2011, 219(1):65-73.
[11] Ding Y, Feng Y, Zhu WW, et al. [Gly14]-humanin prevents lipid deposition and endothelial cell apoptosis in a lectinlike oxidized low-density lipoprotein receptor-1-dependent manner[J]. Lipids, 2019, 54(11/12):697-705.
[12] Li WF, Zhang DD, Yuan WJ, et al. Humanin ameliorates free fatty acid-induced endothelial inflammation by suppressing the NLRP3 inflammasome[J]. ACS Omega, 2020, 5(35): 22039- 22045.
[13] Yuan T, Yang T, Chen H, et al. New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis[J]. Redox Biol, 2019, 20:247-260.
[14] Wang XH, Wu ZH, He YY, et al. Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2[J]. Mol Immunol, 2018, 101:245-250.
[15] Jha P, Das H. KLF2 in regulation of NF-κB-mediated immune cell function and inflammation[J]. Int J Mol Sci, 2017, 18(11):2383.
[16] Ding Y, Feng Y, Zou YT, et al. [Gly14]-humanin restores cathepsin D function via FPRL1 and promotes autophagic degradation of Ox-LDL in HUVECs[J]. Nutr Metab Cardiovasc Dis, 2020, 30(12):2406-2416.
[17] Muzumdar RH, Huffman DM, Calvert JW, et al. Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice[J]. Arterioscler Thromb Vasc Biol, 2010, 30(10):1940-1948.
[18] Thummasorn S, Shinlapawittayatorn K, Chattipakorn SC, et al. High-dose humanin analogue applied during ischemia exerts cardioprotection against ischemia/reperfusion injury by reducing mitochondrial dysfunction[J]. Cardiovasc Ther, 2017, 35(5):28726291.
[19] Wang YY, Li NY, Zeng ZY, et al. Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway[J]. Mol Hum Reprod, 2021, 27(2): gaaa081.
[20] Klein LE, Cui LG, Gong ZW, et al. A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts[J]. Biochem Biophys Res Commun, 2013, 440(2):197-203.
[21] Thummasorn S, Shinlapawittayatorn K, Khamseekaew J, et al. Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity[J]. Mitochondrion, 2018, 38:31-40.
[22] López B, Ravassa S, Moreno MU, et al. Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches[J]. Nat Rev Cardiol, 2021, 18(7):479-498.
[23] Qin Q, Mehta H, Yen K, et al. Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice[J]. Am J Physiol Heart Circ Physiol, 2018, 315(5):H1127-H1136.
[24] Juhaszova M, Zorov DB, Yaniv Y, et al. Role of glycogen synthase kinase-3beta in cardioprotection[J]. Circ Res, 2009, 104(11):1240-1252.
[25] Widmer RJ, Flammer AJ, Herrmann J, et al. Circulating humanin levels are associated with preserved coronary endothelial function[J]. Am J Physiol Heart Circ Physiol, 2013, 304(3):H393-H397.

备注/Memo

备注/Memo:
基金项目：国家自然科学基金（82170450）
通信作者：蒋利，E-mail：jiangli@shtrhospital.com
更新日期/Last Update: 2022-12-20