[1]王姣,彭石,刘丽芳,等.生物钟基因在缺血再灌注及心肌重构中的研究[J].国际心血管病杂志,2022,04:200-202.
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生物钟基因在缺血再灌注及心肌重构中的研究(PDF)
《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]
- 期数:
- 2022年04期
- 页码:
- 200-202
- 栏目:
- 综述
- 出版日期:
- 2022-08-30
文章信息/Info
- Title:
- -
- Author(s):
- -
- Keywords:
- -
- 分类号:
- -
- DOI:
- 10.3969/j.issn.1673-6583.2022.04.003
- 文献标识码:
- -
- 摘要:
- 急性心肌梗死后缺血再灌注损伤是冠状动脉粥样硬化性心脏病（冠心病）常见 的损伤加重原因。正常生物钟节律使机体适应外界环境变化，研究发现生物钟节律紊乱在心 肌缺血再灌注及心肌重构中发挥重要作用。生物钟基因紊乱可能通过增加炎性因子及活性 氧生成、阻碍线粒体自噬、加重铁死亡及生物钟自噬等多个方面加重缺血再灌注损伤，干扰 心肌重构，导致心血管事件预后恶化。研究生物钟基因在缺血再灌注及心肌重构过程中可能 的作用机制，有望为冠心病提供重要的治疗策略。
- Abstract:
- -
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备注/Memo
- 备注/Memo:
-
基金项目：甘肃省卫生行业科研计划项目（GSWSKY-2015-44）
通信作者：姚亚丽， E-mail: yaoyali6373@163.com
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