Title:

The effect of miR-17-5p on ventricular remodeling after acute myocardial infarction by targeting the expression of TP53INP1

作者：

朵杰, 白洁, 韩琼

朵杰,白洁,韩琼

Author(s):

DUO Jie, BAI Jie, HAN Qiong.

DUO Jie, BAI Jie, HAN Qiong.

单位:

目的：探讨微小RNA（miRNA）miR-17-5p 通过靶向调控肿瘤蛋白53 诱导性 核蛋白1（TP53INP1）的表达对急性心肌梗死（AMI）后心室重构的影响。方法：选取成年 miR-17-5p-/-、miR-17-5p＋/＋和正常型SPF 级昆明种小鼠各20 只，采用随机数字表法分为假 手术组、AMI 组、miR-17-5p-/- 假手术组、miR-17-5p-/-AMI 组，miR-17-5p＋/＋假手术组和 miR-17-5p＋/＋AMI 组，每组10 只，雌雄各半。构建小鼠AMI 模型，采用超

Unit:

Department of Hypertension, Qinghai Cardiovascular and Cerebrovascular Disease Hospital, Xining 810000, China

Keywords:

MiR-17-5p; Tumor protein 53-inducible nuclear protein 1; Acute myocardial infarction; Ventricular remodeling

DOI:

10.3969/j.issn.1673-6583.2022.02.015

摘要:

微小RNA-17-5p ；肿瘤蛋白53 诱导性核蛋白1 ；急性心肌梗死；心室重构

Abstract:

Objective: To investigate the effect of miR-17-5p on ventricular remodeling after acute myocardial infarction (AMI) by targeting the expression level of tumor protein 53-inducible nuclear protein 1 (TP53INP1). Methods: Twenty adult Kunming SPF mice with m

参考文献
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备注/Memo:

作者单位：810000 西宁, 青海省心脑血管病专科医院高血压科
通信作者：朵杰, E-mail:commendf@sina.com