|本期目录/Table of Contents|

[1]郑云涛,邓兵,郑望,等.麝香通心滴丸对急性心肌梗死经皮冠状动脉介入治疗患者炎性因子及心功能的有益作用[J].国际心血管病杂志,2021,02:116-119.
　ZHENG Yuntao,DENG Bing,ZHENG Wang,et al.Beneficial effects of She Xiang Tong Xin Dropping Pill on cytokines and left ventricular function in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention[J].International Journal of Cardiovascular Disease,2021,02:116-119.
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麝香通心滴丸对急性心肌梗死经皮冠状动脉介入治疗患者炎性因子及心功能的有益作用(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2021年02期
页码:
116-119
栏目:
临床研究
出版日期:
2021-03-20

文章信息/Info

Title:
Beneficial effects of She Xiang Tong Xin Dropping Pill on cytokines and left ventricular function in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention
作者:
郑云涛; 邓兵; 郑望; 沈琳; 李广浩; 汤诺
200032 上海中医药大学附属龙华医院心内科
Author(s):
ZHENG Yuntao;  DENG Bing;  ZHENG Wang;  SHEN Lin;  LI Guanghao;  TANG Nuo
Department of Cardiology, Long Hua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
关键词:
经皮冠状动脉介入治疗;  冠状动脉粥样硬化性心脏病;  炎性因子;  左心功能;  麝香通心滴丸
Keywords:
Percutaneous coronary intervention;  Coronary artery disease;  Cytokine;  Left ventricular function;  She Xiang Tong Xin Dropping Pill
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2021.02.013
文献标识码:
-
摘要:
目的:探讨麝香通心滴丸对急性ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入治疗(PCI)后炎性因子和心功能的影响。方法:选择2015年1月—2017年12月连续82例STEMI并接受急诊PCI的患者,以1:1随机分为常规治疗组和麝香通心滴丸组(入院后立即口服麝香通心滴丸6丸,次日起2丸/次,每日3次,持续30 d)。测定PCI前及术后7 d血清炎性因子水平及超声心动图左室功能变化。结果:两组患者PCI前血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、高敏C反应蛋白(hsCRP)水平相近(P均>0.05),术后7 d时上述指标均有一定程度的降低,但麝香通心滴丸组炎性因子降低幅度较常规治疗组更大(P均<0.05)。两组PCI前左室收缩末期容量(LVESV)、左室舒张末期容量(LVEDV)、左室射血分数(LVEF)无明显差异,术后7 d左心室容量无显著变化,但LVEF较术前明显增高(P<0.05)。术后30 d时,两组患者LVESV和LVEDV均较术前明显减低,LVEF较术前明显增高,且麝香通心滴丸组LVEF改善的程度优于常规治疗组(P<0.05)。结论:急诊PCI可改善STEMI患者的炎性反应及左心功能,加用麝香通心滴丸有助于进一步改善上述作用。
Abstract:
Objective:To explore the effect of She Xiang Tong Xin Dropping Pill on serum cytokine and left ventricular function in patients with acute ST-segment elevation myocardial infarction(STEMI)undergoing primary percutaneous coronary intervention(PCI).Methods:

参考文献/References

[1] 沈卫峰. 遵循指南优化急性ST段抬高型心肌梗死临床管理[J]. 中华心血管病杂志, 2019, 47(10):762-765.
[2] 中华医学会心血管病学分会, 中华心血管病杂志编辑委员会. 急性ST段抬高型心肌梗死诊断和治疗指南(2019)[J]. 中心血管病杂志, 2019, 47(10):766-783.
[3] Ibanez B, James S, Agewall S, et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology(ESC)[J]. Eur Heart J, 2018, 39(2):119-177.
[4] Ndrepepa G, Colleran R, Kastrati A. Reperfusion injuring in ST-segment elevation myocardial infarction: the final frontier[J]. Coron Artery Dis, 2017, 28(5):253-262.
[5] 张贵峰, 赖永新. 麝香通心滴丸治疗冠心病心绞痛气虚血瘀证的临床疗效[J]. 现代诊断与治疗, 2015, 26(5):994-995.
[6] Lin S, Chu J, Zhang L, et al. Protective effects of Shexiang Tongxin Dropping Pill on pituitrin induced acute myocardial ischemia in rats[J]. Mol Med Rep, 2017, 16(3):3125-3132.

备注/Memo

备注/Memo:
通信作者:郑望,E-mail:zwnowayback@126.com
更新日期/Last Update: 2021-03-20