索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]白楠,詹成创,王健,等.青蒿素及其衍生物在心血管疾病中的应用[J].国际心血管病杂志,2021,02:94-97.
点击复制

青蒿素及其衍生物在心血管疾病中的应用(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2021年02期
页码:
94-97
栏目:
综述
出版日期:
2021-03-20

文章信息/Info

Title:
-
作者:
白楠詹成创王健李为民
150001 哈尔滨医科大学附属第一医院心血管内科
Author(s):
-
关键词:
青蒿素 衍生物 心血管病
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2021.02.008
文献标识码:
-
摘要:
青蒿素及其衍生物除抗疟疾外,对心血管系统也具有保护作用。青蒿素通过增加收缩型血管平滑肌细胞基因表达、干扰心室肌细胞动作电位、抑制心肌间质纤维化等机制,发挥抑制动脉粥样硬化、抗心律失常、抑制心肌梗死等作用,为临床治疗心血管系统相关疾病提供新思路。
Abstract:
-

参考文献/References

[1] Tu Y. Artemisinin-a gift from traditional chinese medicine to the world(nobel lecture)[J]. Angew Chem Int Ed Engl, 2016, 55(35):10210-10226.
[2] Laleve A, Panozzo C, Kühl I, et al. Artemisinin and its derivatives target mitochondrial c-type cytochromes in yeast and human cells[J]. Biochim Biophys Acta Mol Cell Res, 2020, 1867(5):118661-118671.
[3] Wang KS, Li J, Wang Z, et al. Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways[J]. Immunopharmacol Immunotoxicol, 2017, 39(1):28-36.
[4] D'Alessandro S, Scaccabarozzi D, Signorini L, et al. The use of antimalarial drugs against viral infection[J]. Microorganisms, 2020, 8(1):85.
[5] Johnson BK, Abramovitch RB. Small molecules that sabotage bacterial virulence[J]. Trends Pharmacol Sci, 2017, 38(4):339-362.
[6] Zhang B, Liu P, Zhou Y, et al. Dihydroartemisinin attenuates renal fibrosis through regulation of fibroblast proliferation and differentiation[J]. Life Sci, 2019, 223:29-37.
[7] Li WD, Dong YJ, Tu YY, et al. Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation[J]. Int Immunopharmacol, 2006, 6(8):1243-1250.
[8] Basatemur GL, Jørgensen HF, Clarke MCH, et al. Vascular smooth muscle cells in atherosclerosis[J]. Nat Rev Cardiol, 2019, 16(12):727-744.
[9] Du H, Zhao Q, Zang H, et al. Artemisinin attenuates the development of atherosclerotic lesions by the regulation of vascular smooth muscle cell phenotype switching[J]. Life Sci, 2019, 237:116943.
[10] Gimbrone MA Jr, García-Cardeña G. Endothelial cell dysfunction and the pathobiology of atherosclerosis[J]. Circ Res, 2016, 118(4):620-636.
[11] Shao BZ, Han BZ, Zeng YX, et al. The roles of macrophage autophagy in atherosclerosis[J]. Acta Pharmacol Sin, 2016, 37(2):150-156.
[12] Martinet W, De Meyer GRY. Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential[J]. Circ Res, 2009, 104(3):304-317.
[13] Cao Q, Du H, Fu X, et al. Artemisinin attenuated atherosclerosis in high-fat diet-fed ApoE-/- mice by promoting macrophage autophagy through the AMPK/mTOR/ULK1 pathway[J]. J Cardiovasc Pharmacol, 2020, 75(4):321-332.
[14] Jiang Y, Du H, Liu X, et al. Artemisinin alleviates atherosclerotic lesion by reducing macrophage inflammation via regulation of AMPK/NF-κB/NLRP3 inflammasomes pathway[J]. J Drug Target, 2020, 28(1):70-79.
[15] Ai J, Gao HH, He SZ, et al. Effects of matrine, artemisinin, tetrandrine on cytosolic [Ca2+]i in guinea pig ventricular myocytes[J]. Acta Pharmacol Sin, 2001, 22(6):512-515.
[16] Qiao G, Li S, Yang B, et al. Inhibitory effects of artemisinin on voltage-gated ion channels in intact nodose ganglion neurones of adult rats[J]. Basic Clin Pharmacol Toxicol, 2007, 100(4):217-224.
[17] Wen H, Jiang H, Lu Z, et al. Carvedilol ameliorates the decreases in connexin 43 and ventricular fibrillation threshold in rats with myocardial infarction[J]. Tohoku J Exp Med. 2009, 218(2):121-127.
[18] Gu Y, Wu G, Wang X, et al. Artemisinin prevents electric remodeling following myocardial infarction possibly by upregulating the expression of connexin 43[J]. Mol Med Rep, 2014, 10(4):1851-1856.
[19] Latronico MV, Condorelli G. MicroRNAs and cardiac conduction[J]. Curr Drug Targets, 2010, 11(8):907-912.
[20] Xu X, Zhang Q, Song H, et al. Effects of artemisinin on ventricular arrhythmias in response to left ventricular afterload increase and microRNA expression profiles in wistar rats[J]. PeerJ, 2018, 6:e6110.
[21] 史钰芳, 杨靖, 苗思露. 青蒿素对心衰兔心功能及窦房结功能的影响[J]. 中国中医药科技, 2020, 27(1):31-34.
[22] Gu Y, Wang X, Wang X, et al. Artemisinin attenuates post-infarct myocardial remodeling by down-regulating the NF-κB pathway[J]. Tohoku J Exp Med, 2012, 227(3):161-170.
[23] Gu Y, Wang X, Wu G, et al. Artemisinin suppresses sympathetic hyperinnervation following myocardial infarction via anti-inflammatory effects[J]. J Mol Histol, 2012, 43(6):737-743.
[24] Levick SP, Widiapradja A. The diabetic cardiac fibroblast: mechanisms underlying phenotype and function[J]. Int J Mol Sci, 2020, 21(3):970.
[25] 李俊龙, 曹新冉, 王莹, 等. 青蒿素对糖尿病心肌病大鼠心功能及纤维化的影响[J]. 上海中医药杂志, 2016, 50(3):70-73.
[26] Hakacova N, Klingel K, Kandolf R, et al. First therapeutic use of artesunate in treatment of human herpesvirus 6B myocarditis in a child[J]. J Clin Virol, 2013, 57(2):157-160.
[27] 林艳荣, 吴锋耀, 谢周华, 等.青蒿琥酯治疗新型冠状病毒肺炎的临床研究[J].中华危重病急救医学, 2020, 32(4):417-420.
[28] Urban N, Schaefer M. Direct activation of TRPC3 channels by the antimalarial agent artemisinin[J]. Cells, 2020, 9(1):202.
[29] Han L, Li J. Canonical transient receptor potential 3 channels in atrial fibrillation[J]. Eur J Pharmaco, 2018, 837:1-7.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81270252)
通信作者:李为民,E-mail:liweimin_2009@126.com
更新日期/Last Update: 2021-03-20