|本期目录/Table of Contents|

[1]胡杨兮 赵仙先 荆清.血脂康对动脉粥样硬化的预防作用[J].国际心血管病杂志,2020,03:157-161.
　HU Yangxi,ZHAO Xianxian,JING Qing.Preventive effects of Xuezhikang on atherosclerosis[J].International Journal of Cardiovascular Disease,2020,03:157-161.
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血脂康对动脉粥样硬化的预防作用(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2020年03期
页码:
157-161
栏目:
基础研究
出版日期:
2020-06-08

文章信息/Info

Title:
Preventive effects of Xuezhikang on atherosclerosis
作者:
胡杨兮 赵仙先 荆清
200433 上海,海军军医大学附属长海医院心血管内科
Author(s):
HU Yangxi;  ZHAO Xianxian;  JING Qing
Department of Cardiology, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200433, China
关键词:
斑马鱼;  高脂血症;  血脂康;  动脉粥样硬化
Keywords:
Zebrafish;  Hyperlipidemia;  Xuezhikang;  Atherosclerosis
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2020.03.008
文献标识码:
-
摘要:
目的:探讨血脂康对斑马鱼动脉粥样硬化的预防作用。方法:以二甲基亚砜为阴性对照,辛伐他汀为阳性对照,对斑马鱼脂代谢紊乱模型进行不同浓度的血脂康处理,通过油红O染色、直接测量血脂、荧光显微镜拍照等方法评估血脂康对动脉粥样硬化的预防作用。结果:油红O染色显示血脂康10 μg/mL及以上浓度处理组中幼鱼血管内脂质沉积显著减轻; 脂质含量测定显示血脂康5 μg/mL处理组幼鱼组织匀浆中各类脂质成分明显降低; 荧光显微镜活体观察发现血脂康2 μg/mL及以上浓度处理组幼鱼的中性粒细胞在血管内的募集受到显著抑制。结论:
Abstract:
Objective:To explore the preventive effects of Xuezhikang on atherosclerosis in zebrafish.Methods:Using dimethyl sulfoxide as the negative control and simvastatin as the positive control, the zebrafish models of lipid metabolism disorder were exposed in

参考文献/References

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备注/Memo

备注/Memo:
基金项目:长海医院青年启动基金(CH201805)
作者单位:200433 上海,海军军医大学附属长海医院心血管内科
通信作者:荆清,E-mail:jingqingsmmu@sina.com
更新日期/Last Update: 2020-06-08