[1]陈珍珍 齐超 王珺楠.长链非编码RNA母系表达基因3在心血管疾病中的作用[J].国际心血管病杂志,2019,03:134-136.
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长链非编码RNA母系表达基因3在心血管疾病中的作用(PDF)
《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]
- 期数:
- 2019年03期
- 页码:
- 134-136
- 栏目:
- 综述
- 出版日期:
- 2019-05-27
文章信息/Info
- Title:
- -
- 作者:
- 陈珍珍 齐超 王珺楠
- 130022 长春,吉林大学第二医院
- Author(s):
- -
- Keywords:
- -
- 分类号:
- -
- DOI:
- 10.3969/j.issn.1673-6583.2019.03.002
- 文献标识码:
- -
- 摘要:
- 长链非编码RNA(lncRNA)通过调节细胞增殖、分化、凋亡和转移等过程,影响疾病进展。母系表达基因3(MEG3)属于lncRNA,参与肿瘤、肺动脉高压、肺纤维化、动脉粥样硬化等多种疾病的发病。该文主要介绍MEG3在冠状动脉粥样硬化性心脏病、心力衰竭等疾病中的作用。
- Abstract:
- -
参考文献/References
[1] Yu B, Wang S. Angio-lncRs: lncRNAs that regulate angiogenesis and vascular disease[J]. Theranostics, 2018, 8(13):3654-3675.
[2] 邹燕, 戴盛明. 长链非编码RNA MEG3调控作用相关的信号通路研究进展[J]. 中国免疫学杂志, 2017, 33(11):1741-1743.
[3] Wu Z, He Y, Li D, et al. Long noncoding RNA MEG3 suppressed endothelial cell proliferation and migration through regulating miR-21[J]. Am J Transl Res, 2017, 9(7):3326-3335.
[4] Yang F, Liu W, Yan X, et al. Effects of mir-21 on cardiac microvascular endothelial cells after acute myocardial infarction in rats: role of phosphatase and tensin homolog(PTEN)/vascular endothelial growth factor(VEGF)signal pathway[J]. Med Sci Monit, 2016, 22:3562-3575.
[5] He C, Yang W, Yang J, et al. Long noncoding RNA MEG3 negatively regulates proliferation and angiogenesis in vascular endothelial cells[J]. DNA Cell Biol, 2017, 36(6):475-481.
[6] Boon RA, Hofmann P, Michalik KM, et al. Long noncoding RNA Meg3 controls endothelial cell aging and function: implications for regenerative angiogenesis[J]. J Am Coll Cardiol, 2016, 68(23):2589-2591.
[7] Ruan W, Zhao F, Zhao S, et al. Knockdown of long noncoding RNA MEG3 impairs VEGF-stimulated endothelial sprouting angiogenesis via modulating VEGFR2 expression in human umbilical vein endothelial cells[J]. Gene, 2018, 649:32-39.
[8] Shihabudeen Haider Ali MS, Cheng X, Moran M, et al. LncRNA Meg3 protects endothelial function by regulating the DNA damage response[J]. Nucleic Acids Res, 2018, Nov 22. [Epub ahead of print].
[9] Su W, Xie W, Shang Q, et al. The long noncoding RNA MEG3 is downregulated and inversely associated with VEGF levels in osteoarthritis[J]. Biomed Res Int, 2015, 2015:356893.
[10] Zhan R, Xu K, Pan J, et al. Long noncoding RNA MEG3 mediated angiogenesis after cerebral infarction through regulating p53/NOX4 axis[J]. Biochem Biophys Res Commun, 2017, 490(3):700-706.
[11] Liu J, Li Q, Zhang KS, et al. Downregulation of the long non-coding RNA Meg3 promotes angiogenesis after ischemic brain injury by activating notch signaling[J]. Mol Neurobiol, 2017, 54(10):8179-8190.
[12] Qiu GZ, Tian W, Fu HT, et al. Long noncoding RNA-MEG3 is involved in diabetes mellitus-related microvascular dysfunction[J]. Biochem Biophys Res Commun, 2016, 471(1):135-141.
[13] Zheng X, Wu Z, Xu K, et al. Interfering histone deacetylase 4 inhibits the proliferation of vascular smooth muscle cells via regulating MEG3/miR-125a-5p/IRF1[J]. Cell Adh Migr, 2019, 13(1):41-49.
[14] Gareri C, Iaconetti C, Sorrentino S, et al. miR-125a-5p modulates phenotypic switch of vascular smooth muscle cells by targeting ETS-1[J]. J Mol Biol, 2017, 429(12):1817-1828.
[15] Zhang X,,Liu L, Chen C, et al. Interferon regulatory factor-1 together with reactive oxygen species promotes the acceleration of cell cycle progression by up-regulating the cyclin E and CDK2 genes during high glucose-induced proliferation of vascular smooth muscle cells[J]. Cardiovasc Diabetol, 2013, 12(1):147.
[16] Sun Z, Nie X, Sun S, et al. Long non-coding RNA MEG3 downregulation triggers human pulmonary artery smooth muscle cell proliferation and migration via the p53 signaling pathway[J]. Cell Physiol Biochem, 2017, 42(6):2569-2581.
[17] Liu W, Liu X, Luo M, et al. dNK derived IFN-γ mediates VSMC migration and apoptosis via the induction of lncRNA MEG3: a role in uterovascular transformation[J]. Placenta, 2017, 50:32-39.
[18] Zhu B, Gong Y, Yan G, et al. Down-regulation of lncRNA MEG3 promotes hypoxia-induced human pulmonary artery smooth muscle cell proliferation and migration via repressing PTEN by sponging miR-21[J]. Biochem Biophys Res Commun, 2018, 495(3):2125-2132.
[19] 燕林贞, 燕钦栋, 张顺祥, 等. PTEN对缺氧复氧心肌H9c2细胞凋亡、氧化损伤及免疫炎症因子水平的影响[J]. 中国病理生理杂志, 2018, 34(11):1940-1946.
[20] Gong L, Xu H, Chang H, et al. Knockdown of long non-coding RNA MEG3 protects H9c2 cells from hypoxia-induced injury by targeting microRNA-183[J]. J Cell Biochem, 2018, 119(2):1429-1440.
[21] Zhou N, Fu Y, Wang Y, et al. p27 kip1 haplo-insufficiency improves cardiac function in early-stages of myocardial infarction by protecting myocardium and increasing angiogenesis by promoting IKK activation[J]. Sci Rep, 2014, 4:5978.
[22] 周波, 钱坤, 胡明珠, 季永. PI3K/Akt/FoxO3a/Bim信号通路介导硫化氢后处理对缺氧H9c2心肌细胞的保护作用[J]. 中国药理学通报, 2017, 33(7):971-976.
[23] Piccoli MT, Gupta SK, Viereck J, et al. Inhibition of the cardiac fibroblast-enriched lncRNA Meg3 prevents cardiac fibrosis and diastolic dysfunction[J]. Circ Res, 2017, 121(5):575-583.
[23] Uchida S. Besides imprinting: Meg3 regulates cardiac remodeling in cardiac hypertrophy[J]. Circ Res, 2017, 121(5):486-487.
[25] Su J, Fang M, Tian B, et al. Atorvastatin protects cardiac progenitor cells from hypoxia-induced cell growth inhibition via MEG3/miR-22/HMGB1 pathway[J]. Acta Biochim Biophys Sin(Shanghai), 2018, 50(12):1257-1265.
[26] Limana F, Germani A, Zacheo A, et al. Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac c-kit+ cell proliferation and differentiation[J]. Circ Res, 2005, 97(8):e73-e83.
[27] Huang X, Gao Y, Qin J, et al. The mechanism of long non-coding RNA MEG3 for hepatic ischemia-reperfusion: mediated by miR-34a/Nrf2 signaling pathway[J]. J Cell Biochem, 2018, 119(1):1163-1172.
备注/Memo
- 备注/Memo:
-
基金项目:吉林省重点科技攻关项目(20170204032YY)
通信作者:王珺楠,Email:jdeywjn@163.com
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