|本期目录/Table of Contents|

[1]陈海萍,蒋金法.瑞舒伐他汀对H型高血压患者颈动脉粥样斑块的影响[J].国际心血管病杂志,2018,03:180-182.
 CHEN Haiping,JIANG Jinfa..Effects of rosuvastatin on carotid artery atherosclerotic plaque in patients with H-type hypertension[J].International Journal of Cardiovascular Disease,2018,03:180-182.
点击复制

瑞舒伐他汀对H型高血压患者颈动脉粥样斑块的影响(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2018年03期
页码:
180-182
栏目:
临床研究
出版日期:
2018-05-25

文章信息/Info

Title:
Effects of rosuvastatin on carotid artery atherosclerotic plaque in patients with H-type hypertension
作者:
陈海萍蒋金法
200065 上海,同济大学附属同济医院心内科
Author(s):
CHEN Haiping JIANG Jinfa.
Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
关键词:
H型高血压 同型半胱氨酸 颈动脉粥样斑块 瑞舒伐他汀
Keywords:
H-type hypetension Homocysteine Carotid artery atherosclerotic plaque Rosuvastatin
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2018.03.014
文献标识码:
-
摘要:
目的:探讨瑞舒伐他汀对H型高血压患者的同型半胱氨酸及颈动脉粥样硬化斑块的影响。方法:随机将80例伴有颈动脉粥样斑块的H型高血压患者分成2组,对照组采用常规降压治疗,观察组在常规降压治疗基础上加用瑞舒伐他汀10 mg,每晚1次,治疗12个月。比较两组治疗前后低密度脂蛋白胆固醇(LDL-C)、超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)水平,颈动脉内-中膜厚度(IMT)及动脉硬化斑块的变化。结果:治疗12个月后,观察组LDL-C、hs-CRP、Hcy的水平均较治疗前明显下降(P均<
Abstract:
Objective:To investigate the effects of rosuvastation on homocysteine(Hcy)level and carotid artery atherosclerotic plaque in patients with H-type hypertension.Methods:Eighty H-type hypertension patients with artery atherosclerotic plaque were divided rand

参考文献/References

[1] 胡大一, 俆希平.有效控制“H型”高血压——预防卒中的新思路[J]. 中华内科杂志, 2008, 47(12):976-977.
[2] 张岩, 霍勇.双管齐下治疗H型高血压[J].中国实用内科杂志, 2011, 31(10):737-738.
[3] McCully KS. Homocysteine, vitamine and vascular disease prevention [J]. Am J ClinNutr, 2007, 86(5):1563S-1568S.
[4] Zhu WG, Li S, Lin LQ, et al. Vascular oxidative stress increases dendritic cell adhesion and tyansmigration induced by homocysteine[J]. Cell Immunol, 2009, 254(2):110-116.
[5] Zhang L, Jin M, Hu XS, et al. Homocysteine stimulates nuclear factor kappaB activity and interleukin-6 expression in rat vascular smooth muscle cells[J]. Cell Biol Int, 2006, 30(7):592-597.
[6] Murthy SN, Obregon DF, Chattergoon NN, et al. Rosiglitazone reduces serum homocysteine levels,smooth muscle proliferation,and intimal hyperplasia in Sprague-Dawley rats fed a high methionine diet[J]. Metabolism, 2005, 54(5):645-652.
[7] Homocysteine Studies Collabration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis[J]. JAMA, 2002, 288(16):2015-2022.
[8] 吴志红, 孙玉然, 连晓芳, 等.不同剂量瑞舒伐他汀对老年不稳定心绞痛患者血清同型半胱氨酸及高敏C反应蛋白水平的影响[J]. 疑难病杂志, 2013, 12(10):748-750.
[9] 谢文超, 李平, 王正东, 等.瑞舒伐他汀对女性原发性高血压患者血清同型半胱氨酸和细胞间黏附分子-1的影响[J]. 中国临床医生, 2013, 41(2):66-67.
[10] 张玲姬.瑞舒伐他汀对急性冠脉综合征患者血同型半胱氨酸水平的影响[J]. 中西医结合心脑血管病杂志, 2013, 11(6):675-676.
[11] 颜志钦, 易兴阳, 虞君儒, 等.瑞舒伐他汀强化降脂对缺血性脑卒中血脂及颈动脉粥样硬化斑块的影响[J]. 中国药物与临床, 2013, 13(11):1408-1410.

备注/Memo

备注/Memo:
基金项目:上海市科委引导项目(14411971600)
通信作者:蒋金法,Email:jiangjinfa83@163.com
更新日期/Last Update: 2018-06-01