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[1]李越凡,徐丹,李婷,等.Sirt1对糖尿病心肌病大鼠早期心肌S-腺苷同型半胱氨酸水解酶的调节作用及其机制研究[J].国际心血管病杂志,2017,06:348-351.
　LI Yuefan,XU Dan,LI Ting,et al.Research on the regulation and mechanism of Sirt1 on S-adenosylhomocysteine hydrolase in the early stage of diabetic cardiomyopathy rats[J].International Journal of Cardiovascular Disease,2017,06:348-351.
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Sirt1对糖尿病心肌病大鼠早期心肌S-腺苷同型半胱氨酸水解酶的调节作用及其机制研究(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2017年06期
页码:
348-351
栏目:
基础研究
出版日期:
2017-11-25

文章信息/Info

Title:
Research on the regulation and mechanism of Sirt1 on S-adenosylhomocysteine hydrolase in the early stage of diabetic cardiomyopathy rats
作者:
李越凡; 徐丹; 李婷; 官明德
266042 青岛大学医学院第二附属医院心内科
Author(s):
LI Yuefan;  XU Dan;  LI Ting;  GUAN Mingde
Department of Cardiology, The Second Affiliated Hospital of Medical College of Qingdao University, Shandong 266042, China
关键词:
糖尿病心肌病;  沉默信息调节因子1;  S-腺苷同型半胱氨酸水解酶;  同型半胱氨酸;  S-腺苷甲硫氨酸;  S-腺苷同型半胱氨酸
Keywords:
Diabetic cardiomyopathy;  Silent information regulator 1;  S-adenosylhomocysteine hydrolase;  Homocysteine;  S-adenosylmethionine;  S-adenosyl-L-homocysteine
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2017.06.008
文献标识码:
A
摘要:
目的:通过建立糖尿病大鼠模型,探讨沉默信息调节因子(Sirt1)对S-腺苷同型半胱氨酸水解酶(SAHH)糖尿病心肌病早期的调节作用及其机制。方法:采用高脂饮食联合链脲佐菌素建立2型糖尿病大鼠模型,分为对照组、早期糖尿病模型组(DM组)和白藜芦醇处理组(RES组),RES组给予白藜芦醇2.5 mg/(kg·d)灌胃2周处理。HE染色法观察心肌组织病理结构变化,超声心动图检测心功能相关指标,高效液相色谱法检测同型半胱氨酸(Hcy)、S-腺苷甲硫氨酸(SAM)及S-腺苷同型半胱氨酸(SAH),Western b
Abstract:
Objective:To detect the mechanism of silent information regulator 1(Sirt1)in regulating S-adenosylhomocysteine hydrolase(SAHH)in the early occurrence and development of diabetic cardiomyopathy by establishingdiabetes rat model.Methods:The type 2 diabetes

参考文献/References

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[2] Nakao A, Suzuki H, Ueno H, et al. Discovery and structural analyses of S-adenosyl-L-homocysteine hydrolase inhibitors based on non-adenosine analogs[J]. Bioorg Med Chem, 2015, 23(15):4952-4969.
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[4] Cho EH, Kim EH, Kim WG, et al. Homocysteine as a risk factor for development of microalbuminuria in type 2 diabetes[J]. Korean Diabetes J, 2010, 34:200-206.
[5] Xiao Y, Su X, Huang W, et al. Role of S-adenosylhomocysteine in cardiovascular disease and its potential epigenetic mechanism[J]. Int J Biochem Cell Biol, 2015, 67:158-66.
[6] Kloor D, Osswald H. S-adenosylhomocysteine hydrolase as a target for intracellular adenosine action[J]. Trends Pharmacol Sci, 2004, 25(6):294-297.
[7] 尹茂山,许淑红,王燕,等. 2型糖尿病大鼠主动脉Wnt/β-catenin信号通路的变化及SIRT1的调节作用[J]. 中国药理学通报, 2016, 32(3):337-342.
[8] 尹茂山,牟艳玲. Sirt1与心肌保护[J]. 生命科学, 2015, 27(5):601-607.
[9] Kwak HC, Kim YM, Oh SJ, et al. Sulfur amino acid metabolism in zucker diabetic fatty rats[J]. Biochem Pharmaco, 2015, 96(3):256-266.
[10] Cao Z, Zhang Y, Sun T, et al. Homocysteine induces cardiac hypertrophy by up-regulating ATP7a expression[J]. Int J Clin Exp Pathol, 2015, 8(10):12829-12836.
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备注/Memo

备注/Memo:
通信作者:官明德,Email:guanmde@163.com
更新日期/Last Update: 2017-12-10